Manchester United start life without Ole Gunnar Solskjaer with a huge Champions League showdown at Villarreal, while Chelsea and Juventus face a blockbuster battle.
A 4-1 Premier League hammering at Watford was the final straw for the United board as Solskjaer was sacked on Sunday.
Michael Carrick has stepped in to take charge on an interim basis and must rally the troops for the clash between the top two in Group F at Estadio de la Ceramica.
Juventus are already assured of a place in the round of 16 and Chelsea will join them in qualifying from Group H if they avoid defeat at Stamford Bridge.
Barcelona take on Benfica in their first Champions League match with Xavi as boss knowing a win will see them through.
Here, Stats Perform takes a look at the key Opta data for the fixtures on Tuesday.
Villarreal v Manchester United: Red Devils in troubled waters ahead of Yellow Submarine showdown
Villarreal have failed to beat United in five Champions League matches, drawing four and losing one.
The LaLiga side did get the better of the Red Devils in the Europa League final last season on penalties, though, and may never have a better opportunity to consign them to a defeat in Europe’s premier club competition.
Carrick takes charge for the first time following Solskjaer’s departure and will need United to tighten up at the back as they look to end a four-match winless away run in the Champions League. The wounded Premier League side have not kept a clean sheet in the competition this season.
Chelsea v Juventus: Bianconeri plotting another Italian job on holders
Juventus could win the group if they halt Chelsea’s nine-match unbeaten run, as they lead the holders by three points.
The Premier League leaders have not lost since they went down 1-0 to Juve in September and they are overdue a victory against Italian opponents.
Chelsea have not come out on top in their past four meetings against Italian teams and Juve could become the first side to record three consecutive wins over the London club in the Champions League.
Barcelona v Benfica: Pressure on for Xavi’s Champions League bow
Xavi celebrated a derby victory over Espanyol in his first game as Barcelona boss on Saturday and another win over Benfica will secure qualification from Group E.
Third-placed Benfica beat Barca 3-0 in September and will attempt to become only the third side to do the double over the Catalan club in the group stage, Dynamo Kiev in 1997-98 and Bayern Munich in 1998-99 being the others to achieve that feat.
Barca are two points ahead of Benfica following back-to-back 1-0 wins over Dynamo and are looking to keep clean sheets for three consecutive Champions League games for the first time since May 2019.
Sevilla v Wolfsburg: Los Nervionenses nearing last chance saloon
Sevilla dropped points when they were held to a 2-2 draw by Deportivo Alaves in LaLiga on Saturday, and they can ill afford to slip up when they face Wolfsburg.
Bottom of Group G and without a win from four matches, they have not been victorious in their past seven meetings with German sides, losing four and drawing three.
Third-placed Wolfsburg have not been a Spanish team away from home in Europe, losing to Atletico Madrid and Real Madrid either side of a draw with Villarreal.
Dynamo Kiev v Bayern Munich
17 – Bayern have scored 17 goals in their four Champions League matches this season, the joint most by any team after four matches in a season alongside Paris Saint Germain’s tally in 2017-18. Already through to the round of 16, the Group E leaders have also had the most shots (84) and shots on target (34) of any side this campaign.
9 – Dynamo have failed to score in any Champions League matches this season, attempting just nine shots on target – three fewer than Bayern striker Robert Lewandowski has managed in 2021-22 (12).
Lille v Salzburg
43 – Following their 2-1 victory away at Sevilla, Lille will be aiming to record back-to-back wins in the Champions League for the very first time. This will be their 43rd game in the competition.
2 – Salzburg have only won two of their previous 12 away games in major European competition (excluding qualifiers), drawing twice and losing eight times. These 12 games have seen a total of 46 goals scored (19 for, 27 against), at an average of 3.8 per game.
Malmo v Zenit
1 – Zenit have only won one of their past 11 games in the Champions League (D1 L9). That solitary victory and clean sheet in this run of games came in their last meeting with Malmo (4-0 in September).
8 – If Malmo fail to score in this game, they will equal the record for most consecutive games without finding the back of the net in the European Cup/Champions League (currently on 7). The previous instances of a team going eight games in a row without scoring are Dinamo Zagreb (2016), Deportivo La Coruna (2004) and Avenir Beggen (1986).
Young Boys v Atalanta
3 – Since winning three consecutive away Champions League games without conceding a goal between October and December 2020, Atalanta have failed to win each of their past three away games in the competition (D1 L2), conceding eight goals in the process.
4 – Young Boys won their opening group game against United but have since suffered three consecutive defeats in the competition. Bottom of Group F, If they lose this game, they will have suffered four defeats in a row in major European tournaments for the first time.