Des Buckingham enjoyed a first win as Oxford manager as the League One side reached the third round by beating League Two opponents Grimsby 2-0.
The Mariners were unable to repeat last season’s cup exploits when they became the first club in the competition’s history to knock out five teams from higher divisions on their way to the quarter-finals.
Marcus McGuane fired Oxford ahead in the 11th minute and Billy Bodin got the second 15 minutes from time.
It means Buckingham – the former coach of Wellington Phoenix and assistant coach at Melbourne City – took home his first win since taking over as head coach last month, following a successful stint in India with Mumbai City.
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Grimsby were the architects of their own downfall as Oxford’s opener came from their own corner. Josh Murphy raced 60 yards and although Harvey Cartwright parried his drive, McGuane followed up to score.
Otis Khan had two half-chances for Grimsby in the first half and with 20 minutes to go Donovan Wilson was denied by James Beadle’s low save.
Cartwright was much the busier, saving from Stan Mills, twice, and Ruben Rodrigues. The visiting keeper also saved superbly from Bodin and Tyler Goodrham’s drive.
But he could do nothing to stop Bodin nodding in Cameron Brannagan’s chipped cross in the 75th minute to seal Oxford’s progress.